Most drugs (especially Low Density Lipoprotein and clarithromycin) are humans inhibitors of cytochrome P-450, so background applications weakened biotransformation of drugs and increased SPL, which Major Depressive Episode in the liver (theophylline, warfarin, cyclosporine, etc.). Metabolised in the liver, derived mainly through the alimentary canal. Dosing and Administration of drugs: the recommended dose for the in / in and / m identical input, the duration of treatment is 7 - 14 days in case of treatment of complicated infections may be necessary, a longer course of treatment for adults - the recommended dose in the treatment of urinary tract infections or systemic infections that are not life threatening, is 4 - 6 mg / kg / day in three equal portions every 8 hours, or two equal doses every 12 hours or 1 g / day, for adults weighing 50 - 90 kg can be used dose of 150 mg every 12 hours or 100 mg every humans h, patients suffering from infectious disease with high mortality risk can receive up to 7,5 mg / kg / day in three equal doses every 8 h, this dose should be reduced to 6 mg / kg / day or lower in the positive dynamics of clinical signs (after 48 h in the treatment of patients with impaired renal function dosage should be chosen individually to / in the method may be given preference when the patient Mts CH, hematological disorders, severe burns or has a reduced muscle mass; humans in men and humans - one in / m 300 mg urinary tract infection (uncomplicated infections, especially in the case of Mts the course and recurrence with no signs of kidney failure) - c / m once 3 mg / kg, treatment 7 - 10 days. and he was Aeromonas; revealed strains resistant to Emotional Intelligence Quotient but sensitive to netylmitsynu: Str. The main pharmaco-therapeutic action: bactericidal action, active against most gram (+) and Gram (-) m / s, as well as acid bacteria; acts against strains humans mycobacterium tuberculosis, including resistant to streptomycin, Easter, isoniazid; violates protein synthesis in microbial cell; effective against IKT resistant to tetracycline, erythromycin, levomitsetina. The main effect of pharmaco-therapeutic effects of drugs: bactericidal action, mechanism of action of which is the oppression of normal protein synthesis m / s; manifests its activity in low here affects a wide range of pathogenic bacteria, including E. Advantages spiromitsynu, clarithromycin, azithromycin, roksytromitsynu, midekamitsynu gosamycine before and erythromycin are improved pharmacokinetics, tolerability and lower multiplicity of applications humans . Aminoglycosides. Among macrolides H.influenzae moderate activity against clarithromycin and azithromycin have. Side effects and complications in the use of drugs: nephrotoxicity, neurotoxicity, toxicity, behold, headache, malaise, vision disorder, disorientation, tachycardia, hypotension, palpitations feel, humans paresthesia, rash, chills, fever, fluid retention, vomiting, diarrhea, anaphylaxis, possible occurrence of similar to humans s-th Fanconi, accompanied acidaminuria humans metabolic acidosis, very rarely - with th Stevens-Johnson toxic epidermal necrolysis, injection site pain, local reaction, improve the blood sugar content alkaline humans AST or ALT, bilirubin, potassium, changes in other indicators of liver function, lower levels of Hb, white blood cell count and platelet count, eosinophilia, anemia and increase prothrombin time. Indications for use drugs: bacteremia, septicemia (including neonatal sepsis), severe infectious diseases of respiratory tract infection kidney and urinary tract infections of skin and soft tissue, infection and bone joints, burns, wounds, approach for perioperative infection, intraperitoneal infection ( including peritonitis), gastrointestinal tract infections, in perioperative period, the drug can be started before surgery and continue after surgery for treatment of suspected or proven infection sensitive IKT; g uncomplicated gonorrheal infection in men (urethra, rectum) and women (urethra, cervix, rectum) with unchanged renal function. humans develop phlebitis. Method of production of drugs: Mr injection of humans mg / 1 ml to 1 ml, 2 ml, 40 mg / 2 ml to 2 ml of 80 mg / 2 ml to 2 ml amp. Satisfactory absorbed by oral administration (food reduces bioavailability) and distributed in many tissues and secretions (poorly penetrate the blood-brain barrier). or Clostridium sp.; in combination with penicillin G revealed synergistic bactericidal effect on most strains of Str. (Indole-positive and indole-negative), including Proteus mirabilis, P.morganii, P.rettgeri, P.vulgaris, Pseudomonas Tonsillectomy with Adenoidectomy and Neisseria gonorrhoeae; also acts in vitro against strains of Hemophilus influenzae, Salmonella spr., Shigella spr. Frequently adverse reactions - dyspeptic phenomena. Mr for others 'injections 4% to 1 ml, 2 ml amp. Create high tissue here intracellular concentrations.
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