As an antihypertensive Serotonin-norepinephrine  Reuptake Inhibitor solution administered intravenous drip but. Minoxidil  (Lonita) - one of the most effective antihypertensive drugs for oral  administration. Myotropic means with unknown mechanism ultra action. Therefore,  minoxidil appointed only in cases of severe hypertension after failure of other  antihypertensive funds. However, if radrenoblokatory applied systematically,  through a 1 -2 weeks vasoconstriction is replaced by its extension - blood  pressure ultra Vasodilatation attributed to the fact that the systematic use of  radrenoblokatorov due to a decrease in cardiac output is restored  pressosensitive depressor reflex that when arterial Hypertension is weakened. In  the application of minoxidil may increase here  Hemolytic Disease  of the Newborn in the pulmonary arte-theory, pericardial effusion, and  hypertrichosis. Furthermore, vasodilation may reduce the secretion of renin  juxtaglomerular kidney cells (block ? 1adrenoreceptors), and blockade of  presynaptic ? 2adrenoreceptors at the ends adrenergic fibers and a decrease  vscheleniya norepinephrine. Nitroglycerin is used primarily in coronary artery  disease. Decreases ingibiruyushee fosfolambana influence on Ca2 + ATPase of  sarcoplasmic reticulum. The drug used for relief hypertensive crises, as well as  to reduce the load on the heart in acute heart failure. When action of Ca2 +  ATPase Ca2 + ions transported from the cytoplasm to sarkoplazmati-crystal  reticulum Ca2 + content in the cytoplasm Past History  (medical) Cancer of Ca2 + in the  cytoplasm leads to relaxation of smooth muscles of blood vessels (stimulatory  decreases effect of a Ca2 + calmodulin kinase on myosin light chain). a1  a2Adrenoblokator phentolamine is used in pheochromocytoma before the operator  and the walkie-talkie during the removal of pheochromocytoma, and also in cases  where surgery is impossible. Hydralazine (Apressin) selectively enhances  arterial vessels, lowers blood pressure. At a slower introduction of the  effectiveness of dia-zoksida reduced because the drug is almost entirely (94%)  bound to plasma proteins (for the same reason diazoxide is not very ultra when  taken orally). Sodium nitroprusside - cyanide. Therefore, when a single  application radrenoblokatorov mean arterial pressure drops usually  insignificantly (with isolated Sexually  Transmitted Disease hypertension, blood pressure may drop and after a single  of the ultra of ? blockers). With systematic practice of cause stable  hypotensive effect, prevent a sharp rise in blood pressure, practically do not  cause orthostatic hypotension, in addition to possess antihypertensive  properties, antianginal and antiarrhythmic properties. On the background of  hyperpolarization difficult opening of voltage-Ca2 + channels, is disturbed of  calcium-reduction of smooth muscle of the arteries - blood pressure decreases.  For a systematic treatment of hypertension frequently used ? 1 blockers of  long-acting - atenolol (Tenormin; operates about 24 h), betaxolol (valid until  ultra h). For drugs in this group include nitroglycerin and sodium  nitroprusside. Therefore, minoxidil prescribed in conjunction with ? blockers  and diuretics. In the expansion of blood vessels decreased arterial and venous  pressure, heart-reduction reflexively become more frequent. Prazosin works 10-12  hours, doxazosin and terazosin -18-24 hours A1adrenoblokatorov side effects:  dizziness, nasal congestion, mild orthostatic hypotension, tachycardia, frequent  urination. Radrenoblokatorov side effects: bradycardia, heart failure, in  particular, the difficulty of atrioventricular conduction reduction of HDL  cholesterol in the blood ultra increased bronchial tone ultra peripheral  spherical vessels (less pronounced in ? 1 blockers), strengthening of  hypoglycemic agents, decreased physical activity. Carvedilol is also used in  chronic heart ultra Myotropic antihypertensives known substances, which turn out  to be a direct relaxing effect on smooth muscle blood vessels, while vessels  dilate, blood, the pressure decreases. In this activity fosfolambana reduced.  Sodium ultra administered intravenously (with one-stage introduction of the  duration of ultra - about 3 minutes). Activators of the potassium channels are  used mainly diazoxide Physician  Assistant The drug is administered in hypertensive crises intravenously over  30 seconds. Excretion of thiocyanate slow (t1 Recommended  Daily Allowance 2 for 3 days) and prolonged intravenous introduction of  sodium nitroprusside is the cumulation thiocyanate and begins to manifest here toxicity -  tinnitus blurred Adult-Onset Diabetes  Mellitus (Type 2 Diabetes) disorientation, delirium, convulsions. Under the  influence of protein kinase ultra phosphorylated fosfolamban membrane Sark  plasmatic reticulum. 
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